Ockham's Razor Applied on Pharmaceutical Powder Compaction Models

نویسندگان

چکیده

This investigation contains a critical survey of collection five well-known and often used standard models in pharmaceutical technology. The basic idea is to use the recognised Ockham's razor as tool search for simpler methods or explanations these models. study includes indirect tensile strength tablets, Pitt's equation biconvex Adams' model agglomerates, Weibull's distribution variability measurements Heckel's compressibility. In all cases equally valid solutions are presented subsequently preferred rather than original.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Numerical Simulation on Pharmaceutical Powder Compaction

In this paper, we present a modified density-dependent Drucker-Prager Cap (DPC) model with a nonlinear elasticity law developed to describe the compaction behavior of pharmaceutical powders. The model is implemented in ABAQUS with a user subroutine. Using microcrystalline cellulose (MCC) Avicel PH101 as an example, the modified DPC model is calibrated and used for finite element simulations of ...

متن کامل

Compaction of Commercially Pure Titanium Powder by Friction Powder Compaction Process

A new friction powder compaction (FPC) process is introduced for compacting commercially pure titanium powder. The FPC process is very simple and energy-efficient since it requires only a rotating tool plunged into an aluminum plate with a hole filled with titanium powder, and no external heat source is necessary. The sintering of the powder is mainly achieved by the friction heat and pressing ...

متن کامل

Constitutive Equation for Powder Compaction Incorporating Powder Charecteristics

The increasing importance of powdered materials fabrication has led to an increasing emphasis on the understanding of the powder behavior during compaction. During compaction, a powder mass undergoes densification owing to various mechanisms, i.e. sliding, rotation, deformation and/or fracturing of the constituent particles. These densification mechanisms are very dependent upon the powder char...

متن کامل

Influence of the formulation of an alumina powder on compaction

The compression of ceramic powders requires the addition of organic materials to insure tablet cohesion. For the compaction of formulated ceramic powders it is necessary to supply them energy. As a function of the formulation of ceramic powders, one can measure the specific energy acquired during the tablet compression. Recently, a technique used in powder metallurgy, High Velocity Compaction (...

متن کامل

Compaction dynamics of a magnetized powder.

We have investigated experimentally the influence of a magnetic interaction between the grains on the compaction dynamics of a granular pile submitted to a series of taps. The granular material used to perform this study is a mixture of metallic and glass grains. The packing is immersed in homogeneous external magnetic field. The magnetic field induces an interaction between the metallic grains...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Pharmaceutical Sciences

سال: 2021

ISSN: ['0022-3549', '1520-6017']

DOI: https://doi.org/10.1016/j.xphs.2020.11.026